Absence of clinical disease and contact transmission of North American clade 2.3.4.4 H5NX HPAI in experimentally infected pigs

ConclusionsClade 2.3.4.4 H5NX strains can replicate in the lower respiratory tract of swine upon high titer inoculation, though appear to be incapable of replication in swine nasal epithelium in vivo or ex vivo in trachea explants in culture. Infected pigs do not produce high levels of HI antibodies following infection. Collectively, our data show clade 2.3.4.4 HPAI H5NX viruses to be poorly adapted for replication and transmission in swine.This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Firv.12463

Source: Influenza and Other Respiratory Viruses - July 8, 2017 Category: Virology Authors: Bryan S. Kaplan, Mia Kim Torchetti, Kelly M. Lager, Richard J. Webby, Amy L. Vincent Tags: Original Article Source Type: research