Single ‐nucleotide polymorphisms in genes related to the hypothalamic‐pituitary‐adrenal axis as risk factors for posttraumatic stress disorder

This article reviews molecular genetic studies related to PTSD collected through a literature search performed in PubMed, MEDLINE, ScienceDirect, and Scientific Electronic Library Online (SciELO). The results of these studies suggest that several polymorphisms in the HPA axis genes, including FKBP5, NR3C1, CRHR1, and CRHR2, may be risk factors for PTSD development or may be associated with the severity of PTSD symptoms.

Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - July 7, 2017 Category: Genetics & Stem Cells Authors: Carolina M. Carvalho, Bruno M. Coimbra, Vanessa K. Ota, Marcelo F. Mello, Sintia I. Belangero Tags: REVIEW ARTICLE Source Type: research