The effect of the muscarinic M1 receptor antagonist biperiden on cognition in medication free subjects with psychosis

The acetylcholine muscarinic M1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M1 receptor density is related to cognitive symptoms of psychosis. We investigated the role of the M1 receptor in separate cognitive domains in subjects with a psychotic disorder using a muscarinic M1 antagonist as an acute pharmacological challenge. 33 young subjects with a psychotic disorder and 30 gender, age and IQ matched healthy controls were enrolled.

Source: European Neuropsychopharmacology - July 6, 2017 Category: Psychiatry & Psychology Authors: Claudia Vingerhoets, Geor Bakker, Jelske van Dijk, Oswald J.N. Bloemen, Ya Wang, Raymond C.K. Chan, Jan Booij, Therese A.M.J. van Amelsvoort Source Type: research