Antimicrobial activities of streptomyces ceolicolor strain aob kf977550 isolated from a tropical estuary

Publication date: Available online 6 July 2017 Source:Journal of Taibah University for Science Author(s): Bamidele T. Odumosu, Olanike M. Buraimoh, Chiamaka J. Okeke, James O. Ogah, Frederick C. Michel The aim of this study is to screen for antibiotically important Streptomyces from a tropical estuary. Five bacterial strains identified by 16S rDNA gene sequencing as Streptomyces albogriseolus, S. aureus, S. coelicolor, S. albus, and S. pseudogriseolus were isolated from the Lagos Lagoon. Ethyl acetate extracts of the test Streptomyces spp fermented broths were evaluated against laboratory strains of MRSA Staphylococcus aureus 144m, Bacillus coagulans UL001, Escherichia coli and standard strains Klebsiella pneumonia ATCC 8308, Gardnerella vaginalis ATCC 27853 and Salmonella typhi ATCC 13311 using the well diffusion method. The presence of secondary metabolite was determined and analyzed using gas chromatography-mass spectrometer (GC-MS). Broad spectrum of activity was observed for only S. coelicolor on all the tested bacteria except S. typhi, GC-MS analysis revealed the presence of 16 secondary metabolites with antibiotically relevant properties. The result of this study suggest Lagos lagoon is a potential source and reservoir of novel antibiotics.
Source: Journal of Taibah University for Science - Category: Science Source Type: research