CSF IL-10 and IL-10:IL-6 ratio as biomarkers for small B-cell lymphoproliferations with leptomeningeal dissemination

Identifying the etiology of neurological symptoms in blood malignancies is still a challenging issue. Lymphomatous meningitis (LM) is mainly described in aggressive systemic lymphomas (diffuse large B-cell (DLBCL) and Burkitt lymphomas) [1,2]. Leptomeningeal involvement in small B-cell lymphoproliferative disorders (CLPD) is a rare, poorly described condition, only mentioned in a few case-reports [3,4]. The diagnosis is suspected in patients presenting non-specific central nervous system (CNS) symptoms and non-specific results on medical imaging.

Source: Seminars in Hematology - July 6, 2017 Category: Hematology Authors: Myrto Costopoulos, Rathana Kim, Sylvain Choquet, Karim Maloum, Caroline Houillier, Caroline Algrin, Catherine Settegrana, Juliette Villemonteix, Martine Brissard, Claire Quiney, Sophie Bernard, Frederic Davi, Catherine Thieblemont, Khe Hoang-Xuan, Veroniq Source Type: research