Sarcolemmal distribution of ICa and INCX and Ca2+ autoregulation in mouse ventricular myocytes

This study shows that in contrast to the rat, mouse ventricular Na+/Ca2+ exchange current density is lower in the t-tubules than in the surface sarcolemma and Ca2+ current is predominantly located in the t-tubules. As a consequence, the t-tubules play a role in recovery (autoregulation) from reduced, but not increased, sarcoplasmic reticulum Ca2+ release.

Source: AJP: Heart and Circulatory Physiology - July 6, 2017 Category: Cardiology Authors: Gadeberg, H. C., Kong, C. H. T., Bryant, S. M., James, A. F., Orchard, C. H. Tags: RESEARCH ARTICLE Source Type: research