Catalyzing improvements in ALL therapy with asparaginase

Asparaginase remains a cornerstone of ALL therapy and is one of the key contributing factors to improved outcomes in adolescent and young adult (AYA) patients treated on pediatric protocols. Asparagine depletion has been associated with improved outcomes in ALL patients; this has led to an increased emphasis on optimizing asparagine depletion in ALL patients of all ages. To ensure adequate asparagine depletion, the use of therapeutic drug monitoring of asparaginase therapy holds much promise, yet remains underutilized in practice.

Source: Blood Reviews - July 5, 2017 Category: Hematology Authors: Bernard L. Marini, Anthony J. Perissinotti, Dale L. Bixby, Julia Brown, Patrick W. Burke Tags: Review Source Type: research