Impact of HLA ‐DRB1 allele polymorphisms on control of HIV infection in a Peruvian MSM cohort

Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment naïve HIV+ individuals, DRB1*13:02 was linked to elevated viral loads (P = .044) while DRB1*12:01 showed significantly lower viral set points (P = .015) and restricted a dominant T cell response to HIV Gag p24 (P = .038). The present work contributes to a better knowledge of the Peruvian immunogenetics and supports the important role of HLA class II restricted T cells in HIV control.

Source: Tissue Antigens - July 1, 2017 Category: Allergy & Immunology Authors: B. Oriol ‐Tordera, A. Llano, C. Ganoza, S. Cate, W. Hildebrand, J. Sanchez, M. L. Calle, C. Brander, A. Olvera Tags: BRIEF COMMUNICATION Source Type: research