Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye

Conclusions: Hes5‐GFP BAC transgenic mice are useful for identifying Hes5‐expressing cells. Although Hes5‐GFP and Hes1 are coexpressed in particular developmental contexts, we also noted cohorts of lens or retinal cells expressing just one factor. The dynamic Hes5‐GFP expression pattern, coupled with its derepressed expression in Hes1 mutants, suggests that this transgene contains the relevant cis‐regulatory elements that regulate endogenous Hes5 in the mouse lens and retina. This article is protected by copyright. All rights reserved.

Source: Developmental Dynamics - July 1, 2017 Category: Molecular Biology Authors: Amy N. Riesenberg, Kevin W. Conley, Tien T. Le, Nadean L. Brown Tags: Patterns & Phenotypes Source Type: research