Layered Fibrotic Plaques Are the Predominant Component in Cardiac Allograft Vasculopathy: Systematic Findings and Risk Stratification by OCT

Conclusions
OCT enables the detection of CAV-associated plaque compositions and allows early detection and differentiation of vessel wall disease not visible on angiography. LFP was the most prevalent plaque component, was strongly associated with NFCP, and may be associated with stepwise CAV progression caused by organizing mural thrombi. (The GRAFT Study: Evaluation of Graft Function, Rejection and Cardiac Allograft Vasculopathy in First Heart Transplant Recipients; NCT02077764)

Source: Journal of the American College of Cardiology: Cardiovascular Imaging - July 3, 2017 Category: Radiology Authors: Clemmensen, T. S., Holm, N. R., Eiskjaer, H., Logstrup, B. B., Christiansen, E. H., Dijkstra, J., Barkholt, T. O., Terkelsen, C. J., Maeng, M., Poulsen, S. H. Tags: Original Research Source Type: research