Issue Information

Induced pluripotent stem cells derived from a Prader‐Willi syndrome (PWS) patient harboring a deletion on chromosome 15q11.2. The fully methylated chromosome 15q11.2 in PWS‐fibroblasts was successfully reversed to a partially unmethylated status in some PWS‐iPSC lines. Cell replacement‐based therapeutic strategy could be a promising strategy by the reversal of hypermethylation. Further details can be seen in the article by Okuno et al. in this issue.
Source: Congenital Anomalies - Category: Genetics & Stem Cells Tags: Issue Information Source Type: research