Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis

This study identifies a pathogenic role for PC-TP, independent of Them2, in the methionine- and choline-deficient diet model of experimental steatohepatitis. Our current observations suggest that PC-TP promotes liver injury by mediating the intermembrane transfer of phosphatidylcholines, thus stabilizing more pathogenic microvesicular lipid droplets.

http://ajpgi.physiology.org/cgi/content/abstract/313/1/G50?rss=1

Source: AJP: Gastrointestinal and Liver Physiology - July 1, 2017 Category: Gastroenterology Authors: Nicholls, H. T., Hornick, J. L., Cohen, D. E. Tags: RESEARCH ARTICLE Source Type: research