Imaging and modeling of acute pressure-induced changes of collagen and elastin microarchitectures in pig and human resistance arteries

In conclusion, we show here, for the first time in resistance arteries, a quantitative relationship between pressure-induced changes in the extracellular matrix and the arterial wall mechanics. The strength of the integrated methods invites for future detailed studies of microvascular pathologies.
NEW & NOTEWORTHY This is the first study to quantitatively relate pressure-induced microstructural changes in resistance arteries to the mechanics of their wall. Principal findings using a pig model system were confirmed in human arteries. The combined methods provide a strong tool for future hypothesis-driven studies of microvascular pathologies.

Source: AJP: Heart and Circulatory Physiology - July 1, 2017 Category: Cardiology Authors: Bloksgaard, M., Leurgans, T. M., Spronck, B., Heusinkveld, M. H. G., Thorsted, B., Rosenstand, K., Nissen, I., Hansen, U. M., Brewer, J. R., Bagatolli, L. A., Rasmussen, L. M., Irmukhamedov, A., Reesink, K. D., De Mey, J. G. R. Tags: RESEARCH ARTICLE Source Type: research