Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure

This study provides new evidence of early onset (24 h) and continuous (4–12 wk) desmin misarrangement and disruption of the normal sarcomeric and mitochondrial architecture throughout the progression of volume overload heart failure, suggesting a causal link between desmin cleavage and mitochondrial disorganization and damage.

Source: AJP: Heart and Circulatory Physiology - July 1, 2017 Category: Cardiology Authors: Guichard, J. L., Rogowski, M., Agnetti, G., Fu, L., Powell, P., Wei, C.-C., Collawn, J., DellItalia, L. J. Tags: RESEARCH ARTICLE Source Type: research