Electrical Integration of Human Embryonic Stem Cell-Derived Cardiomyocytes in a Guinea Pig Chronic Infarct Model

Conclusions:
Human embryonic stem cell-derived cardiomyocytes engraft in chronically injured hearts without increasing the incidence of arrhythmias, but their electromechanical integration is more limited than previously reported following their transplantation in a subacute injury model. Moreover, non-CM grafts may promote arrhythmias under certain conditions, a finding that underscores the need for input preparations of high cardiac purity.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2014 Category: Cardiology Authors: Shiba, Y., Filice, D., Fernandes, S., Minami, E., Dupras, S. K., Biber, B. V., Trinh, P., Hirota, Y., Gold, J. D., Viswanathan, M., Laflamme, M. A. Tags: Articles Source Type: research