Complement C5a ‐induced changes in neutrophil morphology during inflammation

In conclusion, the data suggest that the anaphylatoxin C5a regulates basic neutrophil cell processes by increasing the membrane elasticity and cell size as a consequence of actin‐cytoskeleton polymerization and reorganization, transforming the neutrophil into a migratory cell able to invade the inflammatory site and subsequently clear pathogens and molecular debris.
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Source: Scandinavian Journal of Immunology - June 30, 2017 Category: Allergy & Immunology Authors: Stephanie Denk, Ronald P. Taylor, Rebecca Wiegner, Erika M. Cook, Margaret A. Lindorfer, Katharina Pfeiffer, Stephan Paschke, Tim Eiseler, Manfred Weiss, Eberhard Barth, John D. Lambris, Miriam Kalbitz, Tobias Martin, Holger Barth, David A. C. Messerer, F Tags: Regular Article Source Type: research