Computational modeling for prediction of the shear stress of three-dimensional isotropic and aligned fiber networks

Interstitial flow (IF) is a creeping flow through the interstitial space of the extracellular matrix (ECM) [1]. IF has been known to play a key role in maintaining tissue homeostasis by transporting cytokines, antigens, nutrients, and various signaling molecules, which have a significant effect on various functions of cells and tissues such as cell differentiation, growth, and tissue remodeling [2 –4]. It also plays a morphoregulator to form blood or lymphatic vessels and induces mechanical strain to align the collagen matrix [5–7].
Source: Computer Methods and Programs in Biomedicine - Category: Bioinformatics Authors: Source Type: research