Comparison of Planar, PET and Well-counter Measurements of Total Tumor Radioactivity in a Mouse Xenograft Model

Quantitative small animal radionuclide imaging studies are often carried out with the intention of estimating the total radioactivity content of various tissues such as the radioactivity content of mouse xenograft tumors exposed to putative diagnostic or therapeutic agents. We show that for at least one specific application, positron projection imaging (PPI) and PET yield comparable estimates of absolute total tumor activity and that both of these estimates are highly correlated with direct well-counting of these same tumors.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research