A GABRA2 Polymorphism Improves a Model for Prediction of Drinking Initiation

Survival analysis was used to explore the addition of a single nucleotide polymorphism (SNP) and covariates (sex, interview age, and ancestry) on a previously published model ’s ability to predict onset of drinking. A SNP variant of rs279871, in the chromosome 4 gene encoding gamma-aminobutyric acid receptor (GABRA2), was selected due to its associations with alcoholism in young adults and with behaviors that increased risk for early drinking.

Source: Alcohol - June 28, 2017 Category: Addiction Authors: Samuel Kuperman, Grace Chan, John Kramer, Leah Wetherill, Laura Acion, Howard J. Edenberg, Tatiana M. Foroud, John Nurnberger, Arpana Agrawal, Andrey Anokhin, Andrew Brooks, Victor Hesselbrock, Michie Hesselbrock, Marc Schuckit, Jay Tischfield, Xiangtao L Source Type: research