Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB ‐PET Study

CONCLUSIONSThe advanced sLASER with FAST(EST)MAP shimming is a promising protocol for identifying glutamate alterations. Advanced 1H‐MRS protocols may add to the understanding of early Alzheimer's disease pathophysiology through detection of glutamate concentration in posterior cingulate gyri of individuals with amnestic mild cognitive impairment.

Source: Journal of Neuroimaging - May 1, 2017 Category: Radiology Authors: Burcu Zeydan, Dinesh K. Deelchand, Nirubol Tosakulwong, Timothy G. Lesnick, Orhun H. Kantarci, Mary M. Machulda, David S. Knopman, Val J. Lowe, Clifford R. Jack, Ronald C. Petersen, G ülin Öz, Kejal Kantarci Tags: Clinical Investigative Study Source Type: research