Cancer: Targeting MYC-driven translation

Nature Reviews Drug Discovery 16, 456 (2017). doi:10.1038/nrd.2017.118 Author: Sarah Crunkhorn Overactivity of the transcription factor MYC plays a central part in the progression of multiple myeloma through upregulation of ribosome synthesis and translation activity. Using a high-throughput screening approach, Manier et al. have identified a series of synthetic analogues of the rocaglate natural product
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research