Finding fault with Bial's fatal FAAH inhibitor

Nature Reviews Drug Discovery 16, 447 (2017). doi:10.1038/nrd.2017.129 Author: Asher Mullard In January 2016, a phase I trial of Bial's oral analgesic BIA 10-2474 killed one volunteer and caused brain damage in four others. The fatal effects of the fatty acid amide hydrolase (FAAH) inhibitor may have been caused by off-target activity on several lipases,
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: News and Analysis Source Type: research