Implications of cancer evolution for drug development

Nature Reviews Drug Discovery 16, 441 (2017). doi:10.1038/nrd.2017.78 Authors: Samra Turajlic & Charles Swanton Tumour evolution, which results in the existence of multiple distinct populations of cancer cells within the same tumour and the same patient, is increasingly appreciated to have a key role in drug resistance. In this article, we discuss the implications for drug development, including approaches to reduce the likelihood of the emergence of drug resistance.
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Comment Source Type: research