OPA1 and cardiolipin team up for mitochondrial fusion

Nature Cell Biology 19, 760 (2017).
doi:10.1038/ncb3565

Authors: Raymond Liu & David C. Chan
Fusion between the inner membranes of two mitochondria requires the GTPase optic atrophy 1 (OPA1), but the molecular mechanism is poorly understood. A study now shows that fusion of two liposomes can be performed by OPA1 tethered to just one liposome, through an interaction with the phospholipid cardiolipin on the opposing liposome.

Source: Nature Cell Biology - June 19, 2017 Category: Cytology Authors: Raymond Liu David C. Chan Tags: News and Views Source Type: research