snoRNAs contribute to myeloid leukaemogenesis

Nature Cell Biology 19, 758 (2017).
doi:10.1038/ncb3566

Authors: Mona Khalaj & Christopher Y. Park
The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of leukaemic-cell self-renewal and growth.

Source: Nature Cell Biology - June 29, 2017 Category: Cytology Authors: Mona Khalaj Christopher Y. Park Tags: News and Views Source Type: research