Impacts of EGFR mutation and EGFR-TKIs on incidence of brain metastases in advanced non-squamous NSCLC

Lung cancer remains the leading cause of cancer-related death among males and the second leading cause of cancer-related death among females in developing countries [1]. Brain is a frequent site of progression in NSCLC, affecting 20% − 40% of patients [2,3]. Adenocarcinoma is more aggressive, and is associated with higher incidence of brain metastases than other subtypes of NSCLC [4]. When brain metastases occur, the survival is generally depressing, with an OS of about 3-6 months [5–7].

Source: Clinical Neurology and Neurosurgery - June 28, 2017 Category: Neurosurgery Authors: Bao-Xiao Wang, Wei Ou, Xiao-Yong Mao, Zui Liu, Hui-Qi Wu, Si-Yu Wang Source Type: research