Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice

Inhibition of the aryl hydrocarbon receptor (AHR) prevents Western diet-induced obesity and fatty liver in C57Bl/6 J (B6) male mice. The AHR is a ligand-activated nuclear receptor that regulates genes involved in xenobiotic metabolism and T cell differentiation. Here, we tested the hypothesis that AHR antagonism would also prevent obesity and fatty liver in female mice and that B6 mice (higher-affinity AHR) and congenic B6.D2 mice (lower-affinity AHR) would differentially respond to AHR inhibition.

Source: Nutrition Research - June 28, 2017 Category: Nutrition Authors: Benjamin J. Moyer, Itzel Y. Rojas, Joanna S. Kerley-Hamilton, Krishnamurthy V. Nemani, Heidi W. Trask, Carol S. Ringelberg, Barjor Gimi, Eugene Demidenko, Craig R. Tomlinson Source Type: research