Recent advances in understanding basophil ‐mediated Th2 immune responses

Summary Basophils, the least common granulocytes, represent only ~0.5% of peripheral blood leukocytes. Because of the small number and some similarity with mast cells, the functional significance of basophils remained questionable for a long time. Recent studies using newly‐developed analytical tools have revealed crucial and non‐redundant roles for basophils in various immune responses, particularly Th2 immunity including allergy and protective immunity against parasitic infections. In this review, we discuss the mechanisms how basophils mediate Th2 immune responses and the nature of basophil‐derived factors involved in them. Activated basophils release serine proteases, mouse mast cell protease 8 (mMCP‐8), and mMCP‐11, that are preferentially expressed by basophils rather than mast cells in spite of their names. These proteases elicit microvascular hyperpermeability and leukocyte infiltration in affected tissues, leading to inflammation. Basophil‐derived IL‐4 also contributes to eosinophil infiltration while it acts on tissue‐infiltrating inflammatory monocytes to promote their differentiation into M2 macrophages that in turn dampen inflammation. Although basophils produce little or no MHC class II (MHC‐II) proteins, they can acquire peptide‐MHC‐II complexes from dendritic cells via trogocytosis and present them together with IL‐4 to naive CD4 T cells, leading to Th2 cell differentiation. Thus, basophils contribute to Th2 immunity at various levels.
Source: Immunological Reviews - Category: Allergy & Immunology Authors: Tags: INVITED REVIEW Source Type: research