Antiproliferative effect of Momordica cochinchinensis seeds on human lung cancer cells and isolation of the major constituents

In this study, we found that its ethanol extract reduced cell proliferation in four human lung cancer cell lines, A549, H1264, H1299 and Calu-6. Phytochemical investigation of the ethanol extract was carried out, and resulted in isolation of two major saponins, which were identified as gypsogenin 3-O- β -d-galactopyranosyl(1 → 2)-[ α -l-rhamnopyranosyl(1 → 3)]- β -d-glucuronopyranoside (1) and quillaic acid 3-O- β -d-galactopyranosyl(1 → 2)-[ α -l-rhamnopyranosyl(1 → 3)]- β -d-glucuronopyranoside (2). Treatment with these isolated compounds (1 and 2) decreased cel1 proliferation in all human lung cancer cell lines tested. In addition, the compounds attenuated primary lung endothelial cell proliferation. Taken together, these findings suggest M. cochinchinensis seeds have antiproliferative activity on human lung cancer cells as well as angiostatic effect on lung endothelial cells.
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research