Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain

Conclusions:
Our present results confirm the physiological relevance of some of the SNPs in the P2RX7 gene and show that the presence of these genetic variants correlates with pain sensitivity also in a diabetic neuropathic pain patient population.

Source: Molecular Pain - June 16, 2014 Category: Molecular Biology Authors: Daniel UrsuPhilip EbertEmily LangronCara RubleLeanne MunsieWei ZouBonnie FijalYue-Wei QianTerry McNearneyAdrian MoggOlivera GrubishaKalpana MerchantEmanuele Sher Source Type: research