Persistent Negative Effects of Alcohol Drinking on Aspects of Novelty-directed Behavior in Male Rhesus Macaques

Humans with histories of prolonged heavy alcohol use exhibit poorer performance on cognitive tasks associated with problem solving, short-term memory, and visuospatial reasoning, even following the cessation of drinking, when compared with healthy controls. It is unclear, however, whether the cognitive problems are a consequence of alcohol exposure or a contributing factor to alcohol-use disorders. Here, we examined the relationship between performance on a novel object recognition (NOR) task and total alcohol consumption (TAC) in adult male rhesus macaques (n = 12; ETH group; trained to self-administer alcohol).

Source: Alcohol - June 24, 2017 Category: Addiction Authors: Cassie M. Chandler, Meagan E. Follett, Nicholas J. Porter, Kevin Y. Liang, Eric J. Vallender, Gregory M. Miller, James K. Rowlett, Donna M. Platt Source Type: research