IRF6 expression in basal epithelium partially rescues Irf6 knockout mice

Conclusion: Together, these data suggest that targeted expression of IRF6 can significantly reduce disease severity, but that a minimum level of Irf6 in both periderm and basal epithelial cells is necessary for orofacial development. Therefore, homologous human and mouse phenotypes are observed for IRF6, IKKA and RIPK4. In this work, we show that altering the expression level of IRF6 dramatically modified this phenotype in utero. This article is protected by copyright. All rights reserved.
Source: Developmental Dynamics - Category: Molecular Biology Authors: Tags: Research Article Source Type: research