Cancer Models: Modeling clear cell renal cell carcinoma

Nature Reviews Cancer 17, 397 (2017). doi:10.1038/nrc.2017.49 Author: Anna Dart A new autochthonous genetically engineered mouse model of clear cell renal cell carcinoma (ccRCC) has been developed by combining deletion of the von Hippel–Lindau tumour suppressor gene (Vhl), Trp53 and Rb1 specifically in renal epithelial cells. Tumours arose from proximal tubule
Source: Nature Reviews Cancer - Category: Cancer & Oncology Authors: Tags: Research Highlight Source Type: research