A New Algebraic Method for Quantitative Proton Density Mapping using Multi-Channel Coil Data

A difficult problem in quantitative MRI is the accurate determination of basic tissue parameters such as the longitudinal relaxation constant T1 (Stikov et al., 2015) and the proton density ρ (Volz et al., 2012a), which are sensitive quantities in measuring brain tissue organization in a number of debilitating conditions such as multiple sclerosis (MS). Using Inversion Recovery (IR) sequences, T1 can be estimated accurately (Stikov et al., 2015). The proton density, however, is more c hallenging to compute than T1 because the transmit and receiver coil sensitivities need to be known as well.

Source: Medical Image Analysis - June 22, 2017 Category: Radiology Authors: Dietmar Cordes, Zhengshi Yang, Xiaowei Zhuang, Karthik Sreenivasan, Virendra Mishra, Le H. Hua Source Type: research