Puberty Arises with Testicular Alterations and Defective AMH Expression in Rams Prenatally Exposed to Testosterone

The male gonadal tissue can be a sensitive target to the reprogramming effects of testosterone (T) during prenatal development. We have demonstrated that male lambs born to dams receiving T during pregnancy – a model system to the polycystic ovary syndrome (PCOS)- show a decreased number of germ cells early in life, and when adult, a reduced amount of sperm and ejaculate volume. These findings are key to put attention to the male offspring of women bearing PCOS, as they are exposed to increased level s of androgen during pregnancy which can reprogram their reproductive outcome.

Source: Domestic Animal Endocrinology - June 22, 2017 Category: Endocrinology Authors: S.E. Recabarren, M. Recabarren, D. Sandoval, A. Carrasco, V. Padmanabhan, R. Rey, H.G. Richter, C.C. Perez-Marin, T. Sir-Petermann, P.P. Rojas-Garcia Source Type: research