Persistently low lymphocyte counts after FCR therapy for chronic lymphocytic leukemia are associated with longer overall survival

In conclusion, lower ALC levels in the first few months following frontline FCR therapy were associated with longer OS and EFS. Possible explanations may be that lower ALCs reflect deeper clonal suppression or protracted Treg depletion. Absolute lymphocyte count levels may be a cheap and widely available prognostic marker, though the added value for clinical practice is the minimal residual disease era needs to be explored.

Source: Hematological Oncology - June 1, 2017 Category: Hematology Authors: Erel Joffe, Ariela Arad N., Osnat Bairey, Riva Fineman, Rosa Ruchlemer, Naomi Rahimi ‐Levene, Lev Shvidel, Uri Greenbaum, Ariel Aviv, Tamar Tadmor, Andrei Braester, Neta Goldschmidt, Aaron Polliack, Yair Herishanu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research