Elsevier launches PharmaPendium DMPK solution

Elsevier, the information analytics company specializing in science and health, has launched the PharmaPendium DMPK (Drug Metabolism-Pharmacokinetic) solution. The DMPK solution delivers searchable pharmacokinetic, metabolizing enzymes and transporters data to provide a complete picture of potential drug-drug interactions (DDIs) and drug candidate risk assessment. PharmaPendium DMPK informs preclinical and clinical risk/benefit analyses – enabling researchers to make quick evaluations of which drug candidates to progress. The DMPK solution also includes a drug-drug interaction risk calculator (DDIRC), which is compliant with 2012 FDA guidelines on Industry Drug Interaction Studies. Together, the solutions support informed and accelerated decision-making. In drug discovery and development, early and ongoing assessment of DDIs is critical. Undetected DDIs can lead to severe side effects, resulting in the refusal of regulatory approval, severe prescribing restrictions or the withdrawal of drugs from the market. The FDA reports that between 1995 and 2010, the proportion of adults dispensed five or more drugs doubled to 20.8%; the proportion dispensed ten or more tripled to 5.8%. DDIs account for between 3-5% of all reported adverse drug events and, with an aging population and this increasing trend towards polypharmacy, are an urgent concern. PharmaPendium’s DMPK Solution provides a unique source of searchable pharmacokinetic, metabolizing enzyme and transporter data and, tog...
Source: News from STM - Category: Databases & Libraries Authors: Tags: European Featured Source Type: news