Fructose intake exacerbates the contractile response elicited by norepinephrine in mesenteric vascular bed of rats via increased endothelial prostanoids

Chronic fructose intake induces major cardiovascular and metabolic disturbances and is associated with the development of hypertension due to changes in vascular function. We hypothesized that high fructose intake for 6 weeks would cause metabolic syndrome and lead to initial vascular dysfunction. Male Wistar rats were assigned to receive fructose (FRU, 10%) or drinking water (CON) for 6 weeks. Systolic blood pressure was evaluated by tail plethysmography. Fasting glucose, insulin and glucose tolerance were measured at the end of the follow-up.

Source: The Journal of Nutritional Biochemistry - June 20, 2017 Category: Biochemistry Authors: Glauciene J. Sousa, Phablo Wendell C. Oliveira, Breno V. Nogueira, Ant ônio F. Melo Junior, Thaís de Oliveira Faria, Eduardo Frizera Meira, José G. Mill, Nazaré S. Bissoli, Marcelo P. Baldo Source Type: research