ω-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice

Many studies have shown that dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) reduces the risks of colorectal cancer, however the underlying mechanisms are not well understood. Here we used a LC-MS/MS-based lipidomics to explore the roles of eicosanoid signaling in the anti-colorectal cancer effects of ω-3 PUFAs. Our results showed th at dietary feeding of ω-3 PUFAs-rich diets suppressed growth of MC38 colorectal tumor, and modulated profiles of fatty acids and eicosanoid metabolites in C57BL/6 mice.

Source: The Journal of Nutritional Biochemistry - June 20, 2017 Category: Biochemistry Authors: Weicang Wang, Jun Yang, Yoshiki Nimiya, Kin Sing Stephen Lee, Katherine Sanidad, Weipeng Qi, Elvira Sukamtoh, Yeonhwa Park, Zhenhua Liu, Guodong Zhang Source Type: research