Drug-induced hypersensitivity syndrome caused by valproic acid as a monotherapy for epilepsy: First case report in Asian population

Publication date: Available online 20 June 2017 Source:Epilepsy & Behavior Case Reports Author(s): X.T. Wu, P.W. Hong, D.J. Suolang, D. Zhou, H. Stefan Valproic acid (VPA) is a broad-spectrum antiseizure drug used for a variety of clinical conditions, such as epilepsy and mood disorders. Drug-induced hypersensitivity syndrome (DRESS) accompanied by hyponatremia, thrombocytopenia, hypoalbuminemia and high aminotransferase has never been reported as an adverse effect of VPA monotherapy during titration for epilepsy in Asian population. Hereby, we present the case of a 73-year-old Chinese male who suffered from DRESS and other complications two weeks after initiating VPA treatment for epilepsy. Understanding the risk associated with VPA-induced DRESS and taking effective measures avoid the severe side effects are necessary.
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research