RUNX2 ‐I is an early regulator of epithelial‐mesenchymal cell transition in the chick embryo

Conclusions: This data introduces the RUNX2‐I isoform as a critical early transcription factor mediating EMT in the developing heart after induction by TGFβ2. Its expression in tumor tissue suggests a similar role for RUNX2 in the EMT of metastasis. This article is protected by copyright. All rights reserved.

Source: Developmental Dynamics - June 20, 2017 Category: Molecular Biology Authors: Andre L.P. Tavares, Jessie A. Brown, Emily C. Ulrich, Katerina Dvorak, Raymond B. Runyan Tags: Research Article Source Type: research