Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the IKs Amplitude in Check Until When Larger IKs Is Needed [Original Articles]

Conclusions— In adult ventricular myocytes, KCNE1 maintains a stable presence on the cell surface, whereas KCNQ1 is dynamic in its localization. KCNQ1 is largely in an intracellular reservoir under basal conditions but can traffic to the cell surface and boost the IKs amplitude in response to stress.

http://circep.ahajournals.org/cgi/content/short/10/6/e005084?rss=1

Source: Circulation: Arrhythmia and Electrophysiology - June 13, 2017 Category: Cardiology Authors: Jiang, M., Wang, Y., Tseng, G.-N. Tags: Arrhythmias, Electrophysiology, Basic Science Research, Cardiomyopathy, Remodeling Original Articles Source Type: research