Patient-Specific Drug Screening Using a Human Induced Pluripotent Stem Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Type 2 [Original Articles]

Conclusions—
These results demonstrate the ability of hiPSCs cardiomyocytes to recapitulate CPVT2 disease phenotype and drug response in the culture dish, to provide novel insights into disease and drug therapy mechanisms, and potentially to tailor patient-specific drug therapy.

Source: Circulation: Arrhythmia and Electrophysiology - June 19, 2017 Category: Cardiology Authors: Maizels, L., Huber, I., Arbel, G., Tijsen, A. J., Gepstein, A., Khoury, A., Gepstein, L. Tags: Arrhythmias, Sudden Cardiac Death, Calcium Cycling/Excitation-Contraction Coupling, Cellular Reprogramming, Stem Cells Original Articles Source Type: research