The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke

Lycopene is a carotenoid with known antioxidant and anti-inflammatory properties. We aimed to evaluate the in vitro and in vivo effects of lycopene on reducing the redox imbalance and inflammation induced by cigarette smoke (CS). For the in vitro study, J774A.1 (Macrophages) cells were incubated in the presence of 0.5, 1.0, 2.0, 4.0, 8.0, 10.0 and 25 μM of lycopene for 3, 6 and 24 h or in the presence of 0.1%, 0,25%, 0.5%, 0.625%, 1.25%, 2.25%, 5% and 10% cigarette smoke extract (CSE) for 3, 6 and 24 h to assess cell viability and measurement of intracellular ROS.

Source: The Journal of Nutritional Biochemistry - June 19, 2017 Category: Biochemistry Authors: K.K.D. Campos, G.R. Ara újo, T.L. Martins, A.C.B. Bandeira, G.P. Costa, A. Talvani, C.C.M. Garcia, L.A. Oliveira, D.C. Costa, F.S. Bezerra Source Type: research