The Arl3 and Arl1 GTPase cooperates with Cog8 to regulate selective autophagy via Atg9 trafficking

In this study, we demonstrate that Arl3‐Arl1 small GTPase cascade cooperates with the subunit of COG complex to control Cvt pathway but not non‐selective autophagy. The yeast strains with dysfunction of Arl3‐Arl1 cascade and COG complex accumulate Atg9 at the late Golgi in nutrient‐rich condition, thereby causing the defect of Cvt pathway. Thus, two Golgi‐endosomal traffic components coordinately regulate the Cvt pathway by regulating Atg9 trafficking at the Golgi.

Source: Traffic - June 19, 2017 Category: Research Authors: I ‐Hao Wang, Yi‐Jie Chen, Jia‐Wei Hsu, Fang‐Jen S. Lee Tags: ORIGINAL ARTICLE Source Type: research