High resolution myelin water imaging incorporating local tissue susceptibility analysis

Quantitative myelin water imaging (MWI) from signal T2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable.

Source: Magnetic Resonance Imaging - June 16, 2017 Category: Radiology Authors: Zhe Wu, Hongjian He, Yi Sun, Yiping Du, Jianhui Zhong Tags: Original contribution Source Type: research