Identification of 400 novel alleles at the HLA ‐A, ‐B, ‐C, ‐DRB1, ‐DQB1 loci from China Marrow Donor Program

Four hundred novel human leukocyte antigen (HLA) alleles were identified in Chinese individuals: 100 HLA‐A alleles, 100 HLA‐B alleles, 101 HLA‐C alleles, 28 HLA‐DRB1 alleles and 71 HLA‐DQB1 alleles. Comparing novel alleles with their most homologous allele, we found 72.73% non‐synonymous nucleotide substitutions, 21.13% silent mutations, 3.90% nonsense mutations and 3.25% frameshift mutation. 352 (88%) of the 400 novel alleles are single nucleotide substitution variants when compared with their most homologous alleles and other novel alleles differ from their most similar allele by more than 1 nucleotide substitutions, such as 2, 3, 5, 6, 8 and so on. Some of the novel alleles are characterized by long deletions or insertions, for example there is 23 bp deletion in the B*58:31N allele when compared to its most homologous allele B*58:01:01:01.
Source: Tissue Antigens - Category: Allergy & Immunology Authors: Tags: BRIEF COMMUNICATION Source Type: research