Structural brain abnormalities in patients with type I bipolar disorder and suicidal behavior

Some studies have identified brain morphological changes in the frontolimbic network (FLN) in bipolar subjects who attempt suicide (SA). The present study investigated neuroanatomical abnormalities in the FLN to find a possible neural signature for suicidal behavior in patients with bipolar disorder type I (BD-I). We used voxel-based morphometry to compare euthymic patients with BD-I who had attempted suicide (n=20), who had not attempted suicide (n=19) and healthy controls (HCs) (n=20). We also assessed the highest medical lethality of their previous SA.

Source: Psychiatry Research: Neuroimaging - April 29, 2017 Category: Psychiatry Authors: Dante G.G. Duarte, Maila de Castro L. Neves, Maicon R. Albuquerque, Gustavo Turecki, Yang Ding, Fabio Luis de Souza-Duran, Geraldo Busatto, Humberto Correa Source Type: research