Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3 β Phosphorylation

Although preconditioning of sphingosine 1-phosphate (S1P) has been shown to protect myocytes from hypoxia reoxgenation injury in  vitro, the role of S1P postconditioning on myocardial ischemia reperfusion injury (MIRI) in vivo and its related mechanism are unknown. The aim of this study was to investigate the protective role of sphingosine 1-phosphate (S1P) postconditioning in MIRI via its effects on mitochondrial signaling and Akt/Gsk3β phosphorylation.

Source: Archives of Medical Research - February 1, 2017 Category: Research Authors: Rui Fang, Lu-lu Zhang, Li-zhi Zhang, Wenchang Li, Mengmeng Li, Ke Wen Tags: Original Article Source Type: research