Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale [Original Articles]

Conclusions— The Gene-Lifestyle Interactions Working Group provides an excellent framework for understanding the lifestyle context of genetic effects and to identify novel trait loci through analysis of interactions. An important and novel feature of our study is that the gene–lifestyle interaction (GxE) results may improve our knowledge about the underlying mechanisms for novel and already known trait loci.

http://circgenetics.ahajournals.org/cgi/content/short/10/3/e001649?rss=1

Source: Circulation: Cardiovascular Genetics - June 15, 2017 Category: Cardiology Authors: Rao, D. C., Sung, Y. J., Winkler, T. W., Schwander, K., Borecki, I., Cupples, L. A., Gauderman, W. J., Rice, K., Munroe, P. B., Psaty, B. M., on behalf of the CHARGE Gene-Lifestyle Interactions Working Group* Tags: Cardiovascular Disease, Lifestyle, Risk Factors, Genetic, Association Studies, Meta Analysis Original Articles Source Type: research